___________________

The Prostate Forum
is published monthly in
Charlottesville, Virginia 
by Rivanna Health
Publications, Inc.
Editor-in Chief
Charles E. Myers, Jr. MD
Publisher
Rose Sgarlat Myers, PT, PhD
Marketing Director

Sara Sgarlat
Associate Editor/Contributor

Jessica Lynn Myers
Staff Editor/Contributor
Rod Schecter

Assistant Editor
Gabrielle Myers
1996-2004
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Back Issues

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Volume 10 Number 7, Vitamin D3 and slow growing recurrent disease.

Volume 10 Number 6, What impact has Michael Dattoli's 2007 Cancer study had on radiation therapy for high-risk prostate cancer?

Volume 10 Number 5, How Prostate cancer spreads and a discussion about whether testosterone replacement after prostate cancer treatment is useful or not.

Volume 10 Number 4, A review of nutritional and supplements for prostate cancer: selenium, lycopene, flaxseed, and red wine.

Volume 10 Number 3, Nutrition Revisited, Part I A primer on evaluating new studies about prostate cancer.

Volume 10 Number 2, This issue offers some final thoughts on the FDA's decision about provenge as well as in-depth discussions of the new warning about Zometa and heart damage; how grilling, frying or roasting meat may affect prostate cancer; whether or not soy increases the risk of advanced disease; regaining erections after surgery, radiation or hormonal therapy; and how to deal with a troublesome (and painful) treatment side effect.

Volume 10 Number 1, Provenge & We now have a robust understanding of how the immune system can act to control cancer progression. We have vaccine strategies that work very well in animal models. There are multiple cancer vaccines in clinical trial for prostate cancer and others malignancies. At the end of March, one of these vaccines for prostate cancer, Provenge, went before the FDA advisory committee and may well attain final approval in May. In this article, we will explain how this vaccine works and why it has faced controversy during the approval process.

Volume 9 Number 12, A further exploration of the risks associated with Dostinex (or cabergoline) for prostate cancer patients. An in-depth discussion of the so-called "Vitamin to treat Prostate Cancer" (Ansentar) being produced by Novacea. ACS releases its 2007 statistics; death rates from prostate cancer are dropping dramatically. A discussion of angiotensin receptor blockers as a novel form of hormonal therapy?

Volume 9 Number 11, Pomegranate fruit, juice or extract may slow prostate cancer progression, but you should let your physician know if you're taking supplements or extract as it may also block CYP3A4. An update on lycopene for prostate cancer patients. An alert about indole-3-carbinol and estradiol interactions, and an investigation into why those of you on estradiol shouldn't be eating large amounts of cabbage or related veggies. A warning for those of you on Dostinex (or cabergoline). An excerpt from Dr. Myers' new book, Beating Prostate Cancer.

Volume 9 Number 10, Relapse Following Radical Prostatectomy, II: Radiation therapy, with or without hormonal therapy, is the most commonly used treatment for prostate cancer that recurs after radical prostatectomy. This practice is largely based on small studies and uses a wide range of radiation therapy techniques and does. More importantly, the studies do not include a randomization comparison with the observation arm only as advocated by the Johns Hopkins group.

Volume 9 Number 9, Relapse Following Radical Prostatectomy, I: With PSA screening becoming wide-spread, an increasing proportion of men are being diagnosed when their cancer appears to be confined to their prostate gland. While radiation therapy has made great strides in its accuracy and efficacy, a majority of patients still choose radical prostatectomy as their first treatment choice. However, like most medical procedures, the radical prostatectomy is not always successful and as a result, as the number of men receiving radical prostatectomy increase, so does the number of men whose cancers come back after surgery.

Volume 9 Number 8, Baby Boomers & Gen X-ers With Prostate Cancer, II: Staging is the process of determining how far the cancer has spread. Most cancers are staged using what is called the TNM approach. T stands for tumor and includes information on the size of the original cancer within the prostate gland and whether it has spread from one side of the gland to the opposite side. We also determine if the tumor has spread outside the gland to adjacent organs.

Volume 9 Number 7, Baby Boomers & Gen X-ers With Prostate Cancer, I: Over the past 12 months we saw close to 500 new patients here at my clinic, American Institute For Diseases Of The Prostate. With this large patient volume comes the opportunity to see some of the less common forms of prostate cancer: over the past two years we’ve seen more than 20 men under the age of 40 with prostate cancer.

Volume 9 Number 6, Hormone Resistance, II: This issue continues our discussion of hormonal therapy. In order to understand this issue, you're going to need to read the first part of the series, Hormonal Therapy, I (Vol 9 #5), so if you haven't take a look yet, please do so. (Order online at www.prostateforum.com/backissues.htm or call 800-305-2432).

Volume 9 Number 5, Hormone Resistance, I: It is an unfortunate fact that in some circles, just like Rodney Dangerfield, hormonal therapy gets no respect. However, the clinical trials show that hormonal therapy can be an extremely effective treatment for prostate cancer at various disease stages.

Volume 9 Number 4, Supplements To Avoid: We've received a lot of e-mails and telephone calls about the list of questionable supplements published in the last issue of Prostate Forum. Apparently, many of you are taking one or more of these supplements and want to know why I don't recommend them...

Volume 9 Number 3, Supplements For PCa Survivors: Over the past few years, I have been asked repeatedly what supplements I take and why. In order for you to understand my approach, you need to know that I regard these supplements as drugs and use much the same methods to evaluate them as I would a drug.

Volume 9 Number 2, Vitamin D & Prostate Cancer: There have been major advances in our understanding of vitamin D over the past several years. The best current dosage estimates are 4 to 5,000 IU of Vitamin D per day. The best estimate for those of us with routine sun exposure would be 2,000 IU. Men with kidney damage or over 80 years old may very likely require calcitriol rather than vitamin D. If it proved impossible to keep calcitriol blood levels above 40 pg/ml, I would consider switching to calcitriol.

Volume 9 Number 1, Managing Lymph Node Metastases: Even after lymph node metastases, the cancer remaining in the prostate gland is still the biggest threat to a patient' continued health. The effectiveness of radiation therapy increases rapidly as the radiation dose moves from 70 to 75 Gray. The side effects of hormonal therapy are quite minor compared with the damage done by recurrent cancer. Once we find cancer in the lymph nodes, it' highly likely that the cancer has also seeded the bone, regardless of what the bone scan shows.

Volume 8 Number 12, Lymph Node Staging: The ProstaScint scan identified close to 80% of known cancerous
nodes compared with only 15% for CT and MRI. The CT and MRI scans do a very poor job of detecting lymph node metastases, making it difficult to justify their continued use for prostate cancer lymph node staging. There’s now a competitor to the ProstaScint scan: the Combidex scan. While the ProstaScint scan with CT fusion is useful, it seems very likely that the Combidex scan will be a major improvement because of its higher resolution.

Volume 8 Number 11, Updates On RP; The Celebrex Controversy: Radical Prostatectomy Revisited - One of the therapies that has been examined more closely this past year is radical prostatectomy (RP). In fact, researchers have spent so much time studying RP that they have more information on it than any other treatment option for newly diagnosed patients. So it’s now possible for us to have a much more accurate discussion of the strengths and limits.

Volume 8 Number 10, Vitamin E - Vioxx, Bextra & Celebrex. Grape Juice: Recent news about vitamin E has forced us to revisit the benefits of this supplement and chime in on the current evidence about the safe and effective dosage for men with prostate cancer as well as for their loved ones.

Volume 8 Number 9, IHT Revisited: Last month, we discussed continuous versus intermittent hormonal therapy and concluded that intermittent hormonal therapy was less toxic and may even be more effective in controlling prostate cancer. This analysis has triggered quite a reaction from patients. Several men have asked whether these principles applied to other prostate cancer treatments. The best way to approach this issue is to ask why intermittent hormonal therapy works in the first place and then ask how those principles might apply elsewhere.

Volume 8 Number 8, Zometa/Aredia Side Effects. IHT: Zometa/Aredia side effect & Intermittent Hormonal Therapy Since I opened my clinic in 2002 I have seen about 700 prostate cancer patients and among them, three cases of jawbone damage related to Zometa. I recommend that all patients have preventative dentistry done before they start bisphosphonate therapy. A recent randomized controlled trial found intermittent hormonal therapy superior to continuous treatment.

Volume 8 Number 7, Omega 3 Fatty Acids, II: Fish or Flax?: Your best bet is to obtain omega 3 from fish, fish oil, or Neuromins, in that order. ALA , the major plant omega 3, increased the risk of prostate cancer by 1.7 fold. ALA from both animal and vegetable sources was associated with an increase in the risk of prostate cancer. Men convert less than4% of ALA to DHA, the omega 3 fat needed for optimal brain function. Fish remains the best source of the omega 3 fats for optimum human health and is much more effective than plant omega 3 fats rich in ALA. Drugs such as Pravacol, Lipitor and Zocor are effective at lowering cholesterol and the evidence for their impact on heart disease is much more impressive than that for alpha linolenic acid, flaxseed, or flaxseed oil.

Volume 8 Number 6, Omega 3 Fatty Acids, I: Fish or Flax?: As little as 200mg of omega 3 fats from fish can reduce the risk of sudden death from irregular heartbeat by 50%. While fish consumption tends to reduce overall prostate cancer risk, it impacts metastatic prostate cancer more dramatically. Flax seed oil actually an inferior source of the omega 3 fats needed to sustain human health. We're asking every prostate cancer survivor to tell one man over forty how important a second opinion is for deciding prostate cancer treatment.

Volume 8 Number 5, Soy & Prostate Cancer: There have been several developments that have restored my confidence in the value of say for men with prostate cancer. Among men whose cancer recurred after surgery or radiation therapy, soy isoflavone administration slowed cancer growth in 84% of cases. I have again made soy a major part of my diet and am taking 100 mg of soy isoflavones twice a day. Black men have the highest incidence of and lowest survival rates from prostate cancer in the world.

Volume 8 Number 4, Physician As Patient: 5 Year Update: Five Year Update In February 1999 I was diagnosed with prostate cancer that had spread to the pelvic lymph nodes and bone marrow. Now that five years have elapsed since my diagnosis, I am still in remission. I chose a very aggressive treatment. Still, it is likely that I have dormant microscopic disease. It is possible to craft a program that suppresses prostate cancer while promoting overall health. Chilis may contain anticancer properties that make them a nutraceutical worthy of notice.

Volume 8 Number 3, Boosting Your Metabolism, II: MCT oil has been shown to effectively reduce body fat, particularly subcutaneous fat, without any loss of muscle mass. It seems fairly straightforward to conclude that caffeine would help weight loss, but I can't find any clinical trials that actually prove the point. I'm concerned with ephedra's potential impact on prostate cancer. There are also a few studies that report increased thermogenesis following consumption of either green tea or oolong (partially fermented) tea. Peppers have become a hot topic for health research.

Volume 8 Number 2, Boosting Your Metabolism, I: Drinking ice water, or ice tea, throughout the day will up your metabolism. There are patients who are at much greater risk from obesity than they are from prostate cancer. In such situations, a high calcium/low calcitriol program may provide the safest way to promote weight loss. Sibuteramine can cause modest weight loss with modest side effects. I would consider it for prostate cancer patients when all other approaches have failed. Orlistat is effective at causing weight loss. But for it to work, you need to combine the drug with a low fat diet. I'm more convinced than ever that successful long-term weight loss and optimal health starts with calorie restriction and exercise.

Volume 8 Number 1, Getting Stronger, Staying Thin, II. Aging muscle requires more protein than young muscle. High-quality, low fat sources of protein include white chicken and turkey, egg whites, and soy protein. a lack of tryptophan may be a significant factor that limits T-cell ability to destroy prostate cancer cells. Turkey breast and whey protein are the richest sources of tryptophan. Creatine supplements may increase your muscle strength. The blueberry is number one in antioxidant power, surpassing 39 other fruits and vegetables in its ability to neutralize free radicals.

Volume 7 Number 12, Getting Stronger, Staying Thin, I: Getting and staying thin is an essential component not only to prostate cancer recovery and prevention, but also to living a long healthy life. Men who undergo androgen withdrawal as a prostate cancer treatment lose muscle and gain body fat much faster than their peers. The process of increasing body fat, decreasing muscle mass and cancer progression are all linked by the hormones leptin, IL-6 and TNF alpha. The bottom line is that if you lose more than one to two pounds a week, you're losing significant muscle mass. Laboratory work with nicotinamide shouldn't cause anyone to stop niacin or Niaspan.

Volume 7 Number 11, Healthy Fats: There are fats that are actually good for you and the Mediterranean diet emphasizes them. The polyphenolic antioxidants that make fresh olives bitter also appear to play an important role in reducing oxidative damage to your body. While almonds have not been specifically tested as a treatment for prostate disease, their high content of monounsaturated fat and phytosterols (especially quercetin) make it likely that they'd have a beneficial impact on BPH. Hazelnuts (or filberts) contain 70-80% oleic acid and are also low in both saturated and polyunsaturated fats. Avocados and avocado oil are rich in monounsaturated fat and are particularly rich in beta sitosterol. they lower bad (LDL) cholesterol and increase good (HDL) cholesterol.

Volume 7 Number 10, Obesity & Prostate Cancer, II: The key to longer life may well be eating less: 1500 calories for women, 1800 for men elevated IGF1 levels, as well as the proteins that appear to be involved in prostate cancer progression, are involved in aging, and can be altered by diet. One of the disadvantages of an Atkins-like high protein diet (particularly one rich in animal protein) is that it stimulates IGF1 production. Sir2 is a gene found in yeast that also plays a critical role in calorie restriction's ability to prolong life. It appears that a reasonable goal is to burn 2,100 calories or more per week-or an average of 300 calories a day.

Volume 7 Number 9, Obesity & Prostate Cancer, I: Obesity not only increases your risk of getting variety of cancers, but also of dying of them. The path to weight loss is as individual as DNA. Put simply, diet must be incorporated into a lifestyle that includes exercise and stress reduction.I cannot recommend CQ-10 for general consumption.

Volume 7 Number 8, Lycopene, Resveratrol, & Immunotherapy: Lycopene and other carotinoids appear to have a significant impact on prostate cancer,as well as diabetes mellitus. Immunotherapy is active against some forms of prostate cancer. Testosterone lessens immune response, while estrogen enhances immune response to a range of antigens, including antigen specific CD4+ cells. We have no credible evidence that resveratrol will kill or slow the growth of prostate cancer in humans, because no clinical trials have been conducted.

Volume 7 Number 7, RT, Part III/Updates on Side Effects/Nutrition: If you chose radiation therapy, seek out a center that offers 3-D conformal radiation therapy or IMRT even if you have to travel to do so. Currently, permanent (rather than temporary) seed implantation is supported more extensively by the published medical literature. Kegel exercises havent been proven to prevent post-RP urinary incontinence in men. A Mediterranean diet combined with Vitamin E and Selenium will help you slow the growth of prostate cancer.

Volume 7 Number 6, Nutrition & Lifestyle Updates: May 2003: A regular program of exercise helps you withstand and recover from prostate cancer treatment. Research suggests that obesity not only increases your risk of getting a variety of cancers, but also of dying of the disease. A separate study found that obese men had 2.5 times the risk of having prostate cancer than non-obese men. Eating fish more than three times a week reduced the risk of prostate cancer but has an even greater impact on the risk of metastatic prostate cancer. Men who eat garlic, and onions may have a significantly lower risk of prostate cancer.

Volume 7 Number 5, Radiation II: April 2003: Through the use of very focused radiation techniques like IMRT and radioactive seed implantation, normal tissue damage can be minimized. the issues discussed are: Urinary tract obstruction, Bladder Urgency and Spasms, Blood in the Urine, Rectal Pain, Spasms and Itching, Blood in the Stool, Radiation-Induced Scarring, Impotence,Trental May Have A Special Role, Nitric Oxide, ACE Inhibitors and Aldosterone.

Volume 7 Number 4, (published February 2003) Radiation I: Hormonal therapy improves radiation's ability to kill cancer within the prostate. Radiation therapy and surgery are equally aggressive approaches to treating prostate cancer localized to the prostate gland. Radiation therapy has proven to be a valuable tool for managing cancer that has spread to the periprostatic fat, seminal vesicles, and pelvic lymph nodes. Antioxidants may compromise radiation therapy. Viagra can often improve erections when radiation-induced scarring of the penile artery is the cause of impotence.

Volume 7 Number 3, (January 2003) Radical Prostatectomy II: Should you choose surgery? Even urologic surgeons disagree about who should undergo radical prostectomy and who should not. The benefit of surgery alone now appears to be so limited that it's possible that radiation therapy, hormonal therapy, or even diet might provide superior results. Treating incontinence and impotence are discussed.

Volume 7 Number 2, (December 2002) Radical Prostatectomy I: It is essential for you and your physician to determine whether your cancer is growing slowly or quickly as well as the likelihood that the cancer has escaped the prostate gland before you choose a treatment. As a general guide the men most likely to be cured by surgery have a Gleason grade of 6 or lower, a PSA less than 10 ng/ml, and a cancer small enough that it cannot be detected by a rectal exam. It is essential to determine where the cancer is in your body because surgery can only cure you if the cancer is still in the prostate gland.

Volume 7 Number 1, (November 2002) Hormonal Therapy: Antiandrogens don't block testosterone production, but rather the cancer cell's ability to use it. Proscar can delay cancer recurrence after surgery, enhance the anticancer activity of antiandrogens or LHRP/antiandrogen combinations, and prolong the "off" period of intermittent hormonal therapy. The standard forms of hormonal therapy aim to remove the amount of testosterone in the blood either via surgical (castration) or medical means (LHRH agonists such as Lupron or Zoladex). Dihydrotestosterone increases the blood supply to the prostate gland far more dramatically than does testosterone. Adding Proscar to an antiandrogen, or a course of Lupron plus an antiandrogen, results in more rapid decline in PSA.

Volume 6 Number 12, Slowing Prostate Cancer Growth: December 2001 (Published October 2002) Proscar delays prostate cance reappearance after intermittent hormonal therapy. High doses of calcitriol may significantly increase the effectiveness of selected chemotherapy drugs. Dostinex reduces prostate cancer's growth rate without causing any significant side effects. Celebrex kills cancer cells (particularly prostate cancer cells) in the laboratory by blocking the action of IGF-1, a factor needed for cancer cell survival. In the laboratory, the major fat in fish oil kills prostate cancer cells. Thalidomide slows the progression of prostate cancer, but has serious side effects.

Volume 6 Number 11, A Broader Perspective: November 2001 (Published September 2002) By adopting the same diet and lifestyle changes that reverse heart disease, you can effectively reduce the growth rate of your cancer by two-thirds. T here are five layers of prostate cancer treatment, going from least to most aggressive. In this issue we'll discuss the first treatment layer-diet and lifestyle. Men with Gleason 6 carcinomas or lower and a PSA under 10 may not need to do anything other than change their lifestyle.

Volume 6 Number 10, Dealing With Pain: October 2001 (Published June 2002). Despite recent advances, many cancer patients still cope with untreated pain. According to the World Health Organization as much as 95% of cancer pain is treatable, but only half of cancer patients receive adequate pain relief. Explicitly describing your pain to your physician and his or her staff is essential to achieving adequate pain relief. NSAIDs form the basis for managing cancer pain by blocking E2, which is commonly produced by prostate cancer.

Volume 6 Number 9, Herbs & Supplements To Avoid: September 2001 (Published May 2002) The Key points of this issue are: Seven out of nine studies show that flax seed oil increases the risk of prostate cancer or cancer progression. Dr. Myers discusses the safest sources of omega-3 fatty acids. What supplements create liver toxicity and decrease the effectiveness of your prescription drugs. What supplements to avoid when undergoing radiation therapy, androgen withdrawal or chemotherapy. There is a special warning for impotent men. and a discussion of African American Men and Prostate Cancer.

Volume 6 Number 8, Melatonin & Kava-Kava: August 2001 (Published April 2002) An in depth discussion of Melatonin its known benefits as well as as those needing further confirmation, such as evidence of activity against cancer and as an antioxidant used in treating anxiety and pain. New warning about Kava-Kava. the PC-Spes debate . Problematic and beneficial drugs. Memorial to William Elwood, consulting editor.

Volume 6 Number 7, Physician as Patient: Update: July 2001 (Published March 2002) .
Recovery. Dr. Myers discusses his prostate cancer, his treatment plan and the road to recovery. He also discusses Prostate cancer in men under sixty-five, and the American Institute for Disease of the Prostate.

Volume 6 Number 6, Vitamin D: June 2001 (Published February 2002). Calcitriol is the active form of Vitamin D. Calcitriol has become one of the more exciting elements in treating prostate cancer. A discussion of Aging , Vitamin D status and bone health, Calcitriol and prostate cancer risks and treatments, and advanced prostate cancer.

Volume 6 Number 5, Antioxidants: An Overview: May 2001 (Published January 2002) There is strong evidence supporting the value of antioxidants in prostate cancer prevention and management. Discussion of major laboratory and clinical results that document the importance of oxidative damage and using antioxidants to prevent it. Adetailed reviewof the individual antioxidants, Selenium, Vitamins E ,C, Glutathione and the green tea polyphenol ECGC.

Volume 6 Number 4, Hormone Resistance IV: April 2001 (published November 2001) Ketaconazole ( Nizoral), Aminoglutethimide (Cytadren), Circumventing the Limits to Hormonal Therapy, Overview of Hormone Resistance

Volume 6 Number 3, Hormone Resistance III: March 2001 (Published October 2001)  Prostate Cancer Cells Are A Moving Target.  Prostate Cancer Cell Progression& p53. rB Protein. Gene Damage In Prostate Cancer.

Volume 6 Number 2, Hormone Resistance II: February 2001 (Published September 2001) Green tea, Quercetion, Reseveratrol, Enhanced Cancer Cell Survival, Insulin & Related Proteins, Bcl-2 & Prostate Cancer Cells, Future Prospects.

Volume 6 Number 1, Hormone Resistance I: January 2001 ( published August 2001) Complete Androgen Blockade, Hormone resistant Prostate cancer, Who develops Hormone-Resistant Prostate Cancer?, Male Sex Hormones, Androgen Receptors, Androgen Receptor Mutations, Increased Androgen Sensitivity, How Prostate Cancer cells become Hypersensitive to Androgen, Increased Androgen ReceptorContent, Androgen Receptor Stabilization, Coactivators of Androgen Receptor, Androgen Receptor Activation, Protein Phosphorylation Controls Cell Growth, Protein Phosphorylation in Prostate Cancer Cells, Interlukin-6, Neuropeptides & Hormone Resistance, Antiandrogens

Volume 5 Number 12, Diet & Radiation Proctitis: December 2000 (published June 2001) Macrobiotic Diet: Safety Concerns, Radiation Proctitis Revisited, Mesalamine and Radiation Proctitis, It is safe to eat nuts? Vegetarian Stuffed Eggplant.

Volume 5 Number 11, Prostate Cancer Screening: November 2000 (published April 2001) An important discussion of the PSA Test, included is a thorough discussion of treatment options. Randomized controlled trials revisited.

Volume 5 Number 10, The Physician Becomes the Patient: Update: October 2000 (published March 2001) An update on Dr. Myers's prostate cancer.

Volume 5 Number 9, Radiation Therapy: September 2000 (Published March 2001) PC-SPES REVISITED, And a St. John's Wort Warning. Radiation Therapy: are you cured? The "PSA Bump". A warning for radiation therapy patients. PC-SPES and hormone sensitive Prostate cancer. PC-SPES and hormone resistant Prostate cancer Pc-SPES side effects. CLA and loss in body fat.

Volume 5 Number 8, Prolactin: August 2000 (Published December 2000)  Elevated Prolactin levels. Prolactin deficiency. Drugs which alter Prolactin's effects.  Prolactin blockers and prostate cancer treatment. Kava Kava.

Volume 5 Number 7, Omega 3 Fatty Acids & Saw Palmetto: July 2000 (Published December 2000) Omega 3 fatty acids, What's new? Quality herbal products. Saw Palmetto. Meatless Protein.

Volume 5 Number 6, Stress & the Progression of Prostate Cancer: June 2000 (Published November 2000) Biology of stress. Catecholamines, Cortisol. Importance of the adrenal gland. {Problems with the stress response. Epinephrine and prostate biology.Medical approaches to stress. Drug-free stress reduction. Miller and Rahe's Questionnaire.

Volume 5 Number 5, Effects of Medications for Other Diseases, I: May 2000 (Published November 2000) Men with prostate cancer can also have other diseases, such as high blood pressure. Management of cancer must be coordinated with these other diseases.

Volume 5 Number 4, Nutritional Supplements & Herbal Products II: April 2000 (published October 2000) Echinacea, plant monophenols and polyphenols, grape seed extract, pycnogenol, cranberries, anthocyanins, vitamin e, and olive oil.

Volume 5 Number 3, Nutritional Supplements & Herbal Products I: March 2000 (published August 2000) Discussion of glutamine and black cohosh root literature, uses, and role, if any, in prostate cancer.

Volume 5 Number 2, Updates on Prostate Cancer: February 2000 (published August 2000) Hormonal therapy and antiangiogenesis, surgery, radiation therapy, and angiogenesis,implications of adjuvant hormonal therapy, antiangiogenic activity of common drugs, green tea and hormonal therapy, patterns of metastatic spread in PC, what kills men with prostate cancer?, alpha-linolenic acid (flaxseed oil), and PSA and prostatitis.

Volume 5 Number 1, Selenium: January 2000 (published July 2000) A thorough discussion of the health benefits of selenium in men with prostate cancer. Selenium is an important mineral for the prevention of prostate cancer and other cancers.

Volume 4 Number 12, Simultaneous Treatment of Hot Hlashes and Depression.December 1999 (published July 2000) Discussion of anxiety and depression in prostate cancer and the drugs used in treatment. Discussion of drugs or herbs used in the treatment of hot flashes.

Volume 4 Number 11, Prostatitis & Complications for Diagnosis: November 1999 (published May 2000)

Volume 4 Number 10, CLA; Aspirin & Related Drugs; Complications of Local Treatment: October 1999 (published April 2000) Aspirin and related drugs in prostate cancer, Complications of surgery vs. brachytherapy (seeds). Radiation therapy-induced cancer.

Volume 4 Number 9, Zinc, Caffeine, & Estrogen Patches: September 1999 (published March 2000): Zinc and its role in prostate cancer. Caffeine may be good for you. Estrogen patches for the treatment of hot flashes.

Volume 4 Number 8, Hormone Resistant Disease is Not Inevitable: August 1999 (published Feb 2000) Evidence of hope in hormonal therapy. New Treatment for Late Radiation Toxicity. Chondroitin Sulfate and Glucosamine. Recipe from Eating Your Way to Better Health.

Volume 4 Number 7, Radiation Therapy Part II: July 1999 - Advantages and disadvantages of Radiation Therapy.

Volume 4 Number 6, Adjuvant Hormonal Therapy, Staging, & Chondroitin Sulfate: June 1999 - ProstaScint scan update. Prevention and treatment of breast enlargement.

Volume 4 Number 5, Radiation Therapy Part I: May 1999 - All about Radiation Therapy.

Volume 4 Number 4, The Physician Becomes the Patient: April 1999 - As a subscriber to this newsletter you recently received a letter notifying you that I have prostate cancer. One of the first decisions Rose and I have to face was whether or not to keep my disease a secret.

Volume 4 Number 3, Locally Advanced Prostate Cancer: March 1999 - How prostate cancer spreads. Partin tables. Endorectal MRI, CAT and bone scan. Treatment for Stages 2 and 3. Hormone therapy.

Volume 4 Number 2, Updates on Screening, Diet, & PC-SPES: February 1999 - Screening for prostate cancer. Second chances. More on diet.

Volume 4 Number 1, January 1999 - Familiar prostate cancer, prostate cancer and race. Nutrition.  Importance of PSA doubling time. 

Volume 3 Number 12, Nutrition & Prostate Cancer Part V. Role of Fat in PC: December 1998 - Fat and prostate cancer. Tumors. Herbal products.

Volume 3 Number 11, Exercise: November 1998 - Problems with falls and balance. Principles of exercise. 

Volume 3 Number 10, When Cancer Returns after Radiation: October 1998

Volume 3 Number 9, Watchful Waiting: September 1998

Volume 3 Number 8, Blood Clots: August 1998

Volume 3 Number 7, Important Update on Vitamin D: July 1998

Volume 3 Number 6,Nutrition & Prostate Cancer Part IV. Beta Carotene & Vitamin A: June 1998

Volume 3 Number 5, The Problem of Impotence Part II: May 1998

Volume 3 Number 4, The Problem of Impotence I. Radiation for Recurrent Prostate Cancer: April 1998

Volume 3 Number 2 & 3, When PC Returns after Surgery. Early vs. Late Hormone Therapy. February-March 1998. *COMBINED ISSUE = $7.50

Volume 3 Number 1, Nutrition and Prostate Cancer Part III: January 1998

Volume 2 Number 12, Nutrition & Prostate Cancer Part II. Soy Products; December 1997

Volume 2 Number 11, Nutrition & Prostate Cancer I. Clinical Trial on Calcium & PC: November 1997

Volume 2 Number 10, PC-SPES. Promise & Problems: October 1997

Volume 2 Number 9, What You Need to Know about Clinical Trials. Immunotherapy II: September 1997

Volume 2 Number 8, Immunotherapy Part I: August 1997

Volume 2 Number 7, Radioactive Seeds: July 1997

Volume 2 Number 6, Treatment of Hot Flashes: June 1997

Volume 2 Number 5, Controversial Drugs. PC-SPES: May 1997

Volume 2 Number 4, The Importance of Optimism: April 1997

Volume 2 Number 3, Early and Intermittent Hormone Therapy: March 1997

Volume 2 Number 2, Hormone Therapy. Folic Acid: February 1997

Volume 2 Number 1, Combination Chemotherapy. Selenium for Prevention & Treatment: January 1997

Volume 1 Number 7, First Issue on Chemotherapy. Risks Associated with PC-SPES: December 1996

Volume 1 Number 6, Flax Seed Oil. How Cancer Cells Spread Revisited. PC-SPES. PSMA: November 1996

Volume 1 Number 5, How Prostate Cancer Spreads. RT- PCR for PSA. Eskimos & Fish Fat: October 1996

Volume 1 Number 4, Prostate Cancer & Bones. Vitamin D, Calcium, Exercise, & Fosamax: September 1996

Volume 1 Number 3, How to Graph Your PSA Values. Soy Product Safety: August 1996

Volume 1 Number 2, More Information on Diet and More Detail on Fat. ProstaScint Scan: July 1996

Volume 1 Number 1, Basic Information on Diet with a Special Focus on Fat. Saw Palmetto: June 1996